Improvement of neurological recovery in the insomnia rats by Warming Yang Strategy through targeting SIRT4 by inhibiting inflammation and apoptosis

Abstract The incidence rate of insomnia is increasing, but the mechanism it remains unclear. Warming Yang Strategy (WY) a kind Traditional Chinese Medicine, and proved to be effective in treating patients. animal was established with chlorophenylalanine (PCPA). Morris water maze open field test were performed evaluate influence WY on neurological recovery rats. TUNEL staining flow cytometry used measure apoptosis level. promoted rats through evaluation. increase γ‐aminobutyric acid, dopamine, 5‐hydroxytryptamine, norepinephrine caused by suppressed siSIRT4. decrease inflammation factors expression induced siRNA‐SIRT4 (siSIRT4). improve SIRT4 inhibiting apoptosis. This research might provide novel insight for prevention treatment targeting SIRT4.